In the present investigation preparation of FDT of model drug (glipizide) by using direct compression. Glipizide was complexed with HPβ-CD by microwave method to improve the solubility and dissolution rate before formulating into a dosage form. Glipizide: HPβCD: poloxamer 188 (molar ratio of 1:1:1) complexed by microwave method which gives marked increased in solubility and selected for formulation of FDT. The prepared complex (GLZ) was characterized by DSC, FTIR and XRD studies. Fast dissolving tablet of solubility enhanced glipizide was prepared by direct compression technique because of its ease of access and contain limited number of unit operations. FDT was formulated with various concentrations of excipients like superdisintegrants, binders which were screened to find the best formulation with good friability, disintegration values and % cumulative drug release. Employing a 23 factorial design, the joint influence of two variables like amount of superdisintegrants (SSG) and binder (MCC) on the disintegration time and % CDR. The formulation batches were evaluated for pre-compressional and post-compressional parameters like weight variation, hardness, friability, thickness, disintegration time and dissolution at gastric pH. The values were of post-compressional parameter were in the prescribed limit and results were within IP acceptable limits. The study reveals that the formulation F3 is found to be optimized formulation with 95.10% drug release within 5 min. The kinetic study shows that the fast dissolving formulation follows the first order kinetic for the drug release mechanism.
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